Single cell view of tumor microenvironment gradients in pleural mesothelioma
Giotti, B., Dolasia, K., Zhao, W., Cai, P., Sweeney, R., Merritt, E., Kiner, E., Kim, G. S., Bhagwat, A., Nguyen, T., Hegde, S., Fitzgerald, B. G., Shroff, S., Dawson, T., Garcia-Barros, M., Abdul-Ghafar, J., Chen, R., Gnjatic, S., Soto, A., . . . Tsankov, A. M. (2024). Cancer Discovery, 14(11), 2262–2278. https://doi.org/10.1158/2159-8290.cd-23-0017 Immunotherapies have shown […]
Automated Characterization Method for Validation of Epigenomic Editors in T Cells
Now Watchinghttps://youtu.be/-oRv-U2VMHg To view the transcript click here. Robust characterization methods are important analytical tools for phenotypic characterization in cell and gene therapy. For high-parameter flow cytometry methods, sample preparation is a highly complex and mostly manual procedure. Traditional flow cytometry methods are limited in throughput and resource intensive, which make them suboptimal for discovery screening […]
Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function
Jain, N., Zhao, Z., Koche, R. P., Antelope, C., Gozlan, Y., Montalbano, A., Brocks, D., Lopez, M., Dobrin, A., Shi, Y., Gunset, G., Giavridis, T., & Sadelain, M. (2023). Cancer Discovery, 14(1), 142–157. https://doi.org/10.1158/2159-8290.cd-22-1319 Suboptimal functional persistence limits the efficacy of adoptive T cell therapies. CD28-based chimeric antigen receptors (CARs) impart potent effector function to […]
Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Guo, Y., Bao, Q., Hu, P., & Shi, J. (2023). Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42972-2 Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy. Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral macrophages and dendritic cells. Using a layered double hydroxide nanosheet carrier, we co-deliver a T-type calcium channel inhibitor (TTA-Q6) and […]
Curiox Biosystems to Advance Next-Generation Cancer Cell Therapies Through Collaboration with Leading Cancer Researcher
BOSTON, Sep. 13, 2023 /PRNewswire/ — Curiox Biosystems, a global leader in providing innovative and automated sample preparation solutions for accurate and reproducible cell analysis, is pleased to announce its collaboration with Dr. Marco Ruella, an Assistant Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania (Penn), to support efforts in the […]
Getting to the Heart of the Matter: Novel Analytical Technologies Provide a New Perspective on a Complex Organ
Now Watchinghttps://www.youtube.com/watch?v=R-YT0iVN86c The heart is a 380-million-year-old organ, yet we do not have a complete understanding of the molecular landscape in the normal human adult heart. Of the many molecule classes present in the heart, we are especially lacking in our understanding of the cell surface proteins present on different cell types in the heart. […]
Critical Quality Metrics in Cell Sample Prep for Cell & Gene Therapy Bioanalytics
Now Watchinghttps://youtu.be/vEgp_FSQHF8 In this panel discussion, Virginia Litwin, Ph.D. (CRL), Christoph Eberle, MICR, FRSPH (CRL), Mahwish Natalia, MA, Ph.D. (Takeda Oncology), and Melvin Lye, MBA (Curiox Biosystems) discuss the role of partnerships between early- and late-stream analytical assay developers. While tackling unique challenges in validating flow cytometric methods for Chimeric Antigen Receptor (CAR) T cells, […]
Automating Cell Therapy Product: Constraints and Product Qualification for Fit-to-Process
Now Watchinghttps://www.youtube.com/watch?v=s-ptVJc2HpU When cells matter, it is key to prioritize their care at every stage. Clear resolution and retention of rare cell populations proves to be an issue in cell therapy processing utilizing traditional centrifugation methods. Automated, reproducible sample prep that does not rely on manual handling is the missing piece to saving precious samples, […]
Nothing Mundane, Be Like Jane!
Now Watchinghttps://youtu.be/3LeDxQ5YeRo
AUTO1000: Automate Your Cell Staining Workflow
The Curiox Laminar Wash AUTO 1000 System completely automates the staining and washing workflow, eliminating a major source of variability and enabling process standardization. The AUTO 1000 system offers several key benefits to research and shared resource laboratories in cell and gene therapy discovery and process development, antibody screening, flow core labs, and other applications that rely on cell-based assays.