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Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate-to-severe disease

READ WILEY ONLINE LIBRARY Scientists at Eli Lilly were characterizing circulatory inflammatory profiles and underlying systemic disease heterogeneity within atopic dermatitis (AD) patients. The multiplexing study of several pro-inflammatory mediators distinguished between baseline disease severities, demonstrated by greater EASI, SCORAD Index, Itch NRS and DLQI scores. DropArray Technology provided a 5uL- sample volume workflow, which […]

Primary Human Dendritic Cells and Whole-Blood Based Assays to Evaluate Immuno-Modulatory Properties of Heat-Killed Commensal Bacteria

READ VACCINES Norton, J.E., Jr.; Kommineni, S.; Akrivoulis, P.; Gutierrez, D.A.; Hazuda, D.J.; Swaminathan, G. Primary Human Dendritic Cells and Whole-Blood Based Assays to EvaluateImmuno-Modulatory Properties of Heat-Killed Commensal Bacteria. Vaccines 2021, 9, 225. https://doi.org/10.3390/ vaccines9030225 Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox […]

Large scale cytokine profiling uncovers elevated IL12‑p70 and IL‑17A in severe pediatric acute respiratory distress syndrome

READ SCIENTIFIC REPORTS Investigators in Singapore utilized Curiox’s DropArray (LT210) multiplex immunoassay system to profile 45 cytokines, chemokines, and growth factors in children with severe and non-severe PARDS. This revealed a differential immunological signature correlating with early and late disease, shedding light on PARDs pathophysiology. Judith Ju Ming Wong, Herng Lee Tan, Jieliang Zhou, Jan […]

The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut

READ MICROBIOME Arnold JW, Roach J, Fabela S, et al. The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut. Microbiome. 2021;9(1):31 Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumour

READ NATURE Zappasodi R, Serganova I, Cohen IJ, et al. CTLA-4 blockade drives loss of T reg stability in glycolysis-low tumours. Nature. 2021 Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.