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Getting to the Heart of the Matter: Novel Analytical Technologies Provide a New Perspective on a Complex Organ

The heart is a 380-million-year-old organ, yet we do not have a complete understanding of the molecular landscape in the normal human adult heart. Of the many molecule classes present in the heart, we are especially lacking in our understanding of the cell surface proteins present on different cell types in the heart. Cell surface proteins detect and transmit signals among cells and thus play central roles in cardiac physiology. Clinically, cell surface proteins are a rich source for biomarkers that distinguish cellular phenotypes and disease states, and for targets of drugs or compounds useful in the treatment of cardiac disorders or diseases. Despite their relevance, we have an incomplete understanding of proteins and signaling pathways differentially present in normal or diseased myocardium, a limited number of accessible targets for organ- and cell type-directed drug delivery, and few validated cell type-specific reagents for cell sorting and imaging of cardiac cells.

In this webinar, Dr. Rebekah L. Gundry Ph.D., FAHA describes the development and application of new analytical platforms that enable rapid identification and quantification of cell surface glycoproteins in human heart cells.

Watch this webinar to learn about:

  • The role of unique Laminar Wash™ technology for efficient processing of low-input samples
  • Implementation of Laminar Wash™ technology at various stages of cell isolation and sample preparation for mass spectrometry and flow cytometry
  • How this novel approach yields:
  • unprecedented insight and empirical evidence inaccessible to transcriptomics and generic proteomic approaches
  • exposes previously uncharacterized differences in the surfaceome of cardiomyocytes in failing and non-failing hearts

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