Visit a Curiox Innovation Center before expending capital funds to discover how to transform cell processing workflows with customizable C-FREE automated technologies.
Published on October 1, 2024
Deciding to automate a laboratory process is a significant commitment. In addition to the capital investment, the performance of the automated process must be at least as good as, or better than, the results achieved with the standard manual method.
Consider the traditional cell processing method of centrifugation typically performed prior to cellular analysis techniques such as flow cytometry or mass cytometry (CyTOF). Many labs value the flexibility to use cost-effective centrifuges and manual cell washing techniques before advancing to expensive downstream analyses.
The flexibility of low-tech cell washing procedures is advantageous until inconsistencies and manual errors jeopardize results. For example, a precious cell sample may be lost if a technician spins samples in a tube that is too large, or a medical technician might discard a supernatant of cell populations because the centrifuge was set to revolutions per minute (rpm) instead of relative centrifugal force (RCF).
While low-tech methods are useful, they become a problem if accuracy is not maintained. Small operator miscalculations can escalate into significant problems when research is scaled up, making standardization and precision crucial.
Whether you’re involved in drug discovery, cell therapy, or cellular expansion, the way you manage and scale your samples directly impacts the accuracy and reliability of your research outcomes.
The opportunities to increase standardization, reduce hands-on time, and improve cell viability are all part of the vision behind Curiox Laminar Wash™ and Curiox C-FREE™ technologies for cell processing. Both Laminar Wash and C-FREE technologies eliminate manual centrifugation by using a proprietary laminar flow mechanism to gently wash cells.
Replacing cell centrifugation with laminar washing has the added advantages of improving cell retention, removing more cell debris, and improving resolution of rare cell populations. Numerous labs have published results demonstrating the benefits that laminar wash workflows have brought to their research.
C-FREE technology takes automated sample preparation a step further, as used in the Curiox C-FREE™ Pluto System, by leveraging controlled fluid dynamics to perform buffer exchanges for both washing of cells and beads using a robotic pipette system.
The Pluto system is designed to scale with a laboratory’s specific needs—whether in research or high-throughput clinical settings. Because of the range and flexibility of C-FREE technology, Curiox has established three dedicated Curiox Innovation Centers (CICs) where potential users can experience personalized automation solutions for cell analysis firsthand.
If your lab is ready to adopt an automated cell sample preparation solution, a virtual demo may not fully showcase the complete range of the Pluto system’s capabilities in automating specific scientific workflows.
Visiting a CIC is a great option to help evaluate the following key factors before implementing an automated sample preparation solution:
Establishing an automated sample preparation workflow requires careful consideration of both technical and business factors. By visiting a CIC, a lab can gain a clearer understanding of the strategic implications of automating the sample prep process, ensuring that the investment aligns with both current and long-term research objectives.
Implementing automation is a big challenge to tackle, but Curiox Biosystems is dedicated to creating workflow solutions to help you simplify cell analysis. The first step to workflow transformation is contacting our Curiox team to see where they can help with your specific needs either through more product information or setting up a visit to one of our CICs.
Let us help support your cell analysis breakthrough!
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