Immunopeptidomic MHC-I Profiling and Immunogenicity Testing Identifies Tcj2 as a New Chagas Disease mRNA Vaccine Candidate
Versteeg, L., Adhikari, R., Robinson, G., Lee, J., Wei, J., Islam, N., Keegan, B., Russell, W. K., Poveda, C., Villar, M. J., Jones, K., Bottazzi, M. E., Hotez, P., Tijhaar, E., & Pollet, J. (2024). PLoS Pathogens, 20(12), e1012764. https://doi.org/10.1371/journal.ppat.1012764 Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million […]
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Zhang, X., Song, B., Carlino, M. J., Li, G., Ferchen, K., Chen, M., Thompson, E. N., Kain, B. N., Schnell, D., Thakkar, K., Kouril, M., Jin, K., Hay, S. B., Sen, S., Bernardicius, D., Ma, S., Bennett, S. N., Croteau, J., Salvatori, O., . . . Grimes, H. L. (2024). Nature Immunology, 25(4), 703–715. https://doi.org/10.1038/s41590-024-01782-4 […]
The GENTIL Method for Isolation of Human Adult Cardiomyocytes from Cryopreserved Tissue for Proteomic Analyses
Waknitz, M., Luecke, L. B., Mesidor, R., Wojtkiewicz, M., Castro, C., & Gundry, R. L. (2023). Methods in Molecular Biology, 145–167. https://doi.org/10.1007/978-1-0716-3527-8_9 Heart failure is a serious clinical and economic health care problem, and its clinical progression is linked to pathological cardiac remodeling. Due to the heterogeneity of heart failure, lack of animal models to […]
Laminar Wash Technology: an Overview
Now Watchinghttps://www.youtube.com/watch?v=eoFLbXX2Efc This animation provides an overview of why Laminar Wash represents a disruptive, next-generation technology for optimal cell-containing sample preparation, including what it replaces (centrifuge-reliant methods), how it works (unique plate design plus laminar flow fluidics), and why it is key to bringing sample prep into the 21st century. Highlights include: Introduction to cell washing (0:05) […]
Laminar Wash Technology for Sample Preparation – How it Works
Now Watchinghttps://www.youtube.com/watch?v=2AF8nyanzc4 Laminar Wash technology represents a completely new way to approach cell washing and sample preparation. The system comprises two essential components: a unique plate design and fluidics that generate laminar flow across the sample. This animation covers “how it works” as part of our longer video on Laminar Wash technology. Highlights include: The unique characteristics of the Laminar […]