C-FREE™ Pluto Code – Replace Centrifugation with Pipette-Based Automation
RESOURCES • VIDEO Replace Centrifugation with Pipette-Based Automation Many cell workflows still rely on repeated spin–decant–resuspend steps. C-FREE™ Pluto Code introduces an alternative: pipette-based automation that enables wash-and-mix sequences, without relying on centrifugation. Install the Pluto Code script library into your existing liquid handler for full walkaway workflows, no hardware upgrades required. Request Info View […]
Validated 384-Well C-FREE™ Washing for High-Throughput Cell Prep
Validated 384-Well Centrifuge-Free Washing for High-Throughput Cell Prep Technical and biological validation of centrifuge-free washing at 384-well scale using the C-FREE™ Pluto platform. Enabling high-throughput cell prep automation Moving to 384-well formats increases throughput and reduces reagent use—but washing at this scale introduces real risks: sample loss, uneven retention, and assay variability. This application note […]
From Gentle Wash to Harmonized Workflows: How the Field Scaled Next
By Melvin Lye, Curiox Biosystems For much of the history of flow cytometry, centrifugation has been treated as an accepted compromise. It is efficient, familiar, and deeply embedded in laboratory practice. At the same time, its limitations (cell loss, mechanical stress, and operator-dependent variability) have long been recognized, even if rarely interrogated explicitly in published work. As […]
Harmonization in Cell Preparation: Preserving Data Comparability Across Sites, CROs, and Automation Platforms
By Mallory Griffin, Curiox Biosystems The problem: comparable data starts upstream Cell-based assays have benefited from major advances in instrumentation, reagents, and analysis software. Measurement technologies and data analysis are increasingly automated, standardized, and shared across organizations. Cell preparation, however, remains one of the least controlled parts of the workflow. Even when the same protocol […]
Validating C-FREE™ Pluto Wash: Extending Laminar Wash™ Principles
WHITEPAPER From Laminar Wash™ to Pluto Wash™ — A Fluid‑Dynamics Validation Establishing Reliability of C-FREE™ Pluto Wash Technology through Proven Laminar Wash™ Principles: A Fluid Dynamics–Based Validation Automated. Centrifuge-less. Proven.This whitepaper demonstrates how the C-FREE™ Pluto Wash platform replicates the trusted Laminar Wash™ physics—delivering equivalent recovery, staining, and reproducibility in a fully automated workflow. See […]
Shared Principles, Consistent Results: Pluto Wash vs. Laminar Wash
By Melvin Lye, Senior Director of Scientific Affairs Introduction: Questioning a Long-Held Belief For decades, suspension cell workflows followed a rigid belief: centrifugation and pelleting were the only way to wash cells. This dogma shaped countless assays but also introduced variability, operator fatigue, and cell loss. Curiox challenged this in 2018 with Laminar Wash™ (LW), proving that […]
Pluto Automation: An Introduction to Centrifuge-Less Sample Prep
Automation shouldn’t take 12 months or cost $250k. Pluto reimagines what’s possible in the lab. This short overview introduces how Pluto delivers centrifuge-less cell washing and sample prep automation—making advanced automation accessible for every lab. https://youtu.be/2PxERlWVKkI Why Centrifuge-Less Matters for Cell Washing Traditional centrifuges can stress cells, slow down workflows, and introduce variability. Pluto replaces […]
Advancing Antibody Cocktail Solutions: Empowering CROs with Pluto Automation
By Melvin Lye, Senior Director of Scientific Affairs The preclinical CRO market is projected to reach USD 8.4 billion by 2030, driven by the rise in high-throughput studies and the demand for reproducible biomarker data in drug development. Yet, many Contract Research Organizations (CROs) still rely on manual pipetting for antibody cocktailing, creating bottlenecks that threaten […]
Automating Flow Cytometry Sample Prep: An ROI Calculation
Automating Flow Cytometry Sample Prep: An ROI Calculation Manual flow cytometry sample preparation is labor-intensive and costly, with multiple touchpoints for antibody cocktail prep, cell lysis, and staining. Each manual step adds labor cost, training time, and risk of error. Here we highlight the ROI of automated sample preparation, showing how Pluto Workstation reduces hands-on […]
Unlock Reproducibility in Flow Cytometry — Watch Now
Now Watching https://youtu.be/RTJU6rHmqTE Flow cytometry workflows often suffer from inconsistent results. Variability in cell preparation, preservation, staining, and analysis can compromise your data — and your research. In this short, must-watch video, Dr. Holden Maecker of Stanford HIMC reveals why these issues persist and how automation and standardization can deliver reproducible, high-quality flow cytometry data. […]