Immunopeptidomic MHC-I Profiling and Immunogenicity Testing Identifies Tcj2 as a New Chagas Disease mRNA Vaccine Candidate
Versteeg, L., Adhikari, R., Robinson, G., Lee, J., Wei, J., Islam, N., Keegan, B., Russell, W. K., Poveda, C., Villar, M. J., Jones, K., Bottazzi, M. E., Hotez, P., Tijhaar, E., & Pollet, J. (2024). PLoS Pathogens, 20(12), e1012764. https://doi.org/10.1371/journal.ppat.1012764 Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million […]
Profiling Circulating T cells and Tumor Landscape for Predicting Responses to PD-1 blockade in Patients with Non-Small Cell Lung Cancer
Dutta, N. (2024, September 5). https://gupea.ub.gu.se/handle/2077/81804 Immune checkpoint blockade (ICB) has significantly improved outcomes in non-small cell lung cancer (NSCLC), yet only a subset of patients achieves durable responses. This underscores the need for effective methods to assess ICB efficacy. This thesis investigates the response to PD-1 blockade in NSCLC patients across stages I to […]
Nasal tissue-resident memory CD4+ T cells persist after influenza A virus infection and provide heterosubtypic protection
NimithaR. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angelettihttps://doi.org/10.1101/2024.07.06.602325 CD4 tissue-resident memory T (CD4 TRM) cells are crucial adaptive immune components involved in preventing influenza A virus (IAV) infection. Despite their importance, their physiological role in the upper respiratory tract, the first site of contact with IAV, remains unclear. Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the […]
Immunomodulatory effects and improved outcomes with cisplatin-versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
Galsky, M. D., Guan, X., Rishipathak, D., Rapaport, A. S., Shehata, H. M., Banchereau, R., Yuen, K., Varfolomeev, E., Hu, R., Han, C., Li, H., Liang, Y., Vucic, D., Wang, L., Zhu, J., Yu, H., Herbst, R. H., Hajaj, E., Kiner, E., . . . Mariathasan, S. (2024). Cell Reports Medicine, 5(2), 101393. https://doi.org/10.1016/j.xcrm.2024.101393 In metastatic urothelial […]
Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Guo, Y., Bao, Q., Hu, P., & Shi, J. (2023). Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42972-2 Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy. Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral macrophages and dendritic cells. Using a layered double hydroxide nanosheet carrier, we co-deliver a T-type calcium channel inhibitor (TTA-Q6) and […]
Could Debris Be Masking Your True Results
Now Watchinghttps://www.youtube.com/watch?v=TlQaihGArto Sample preparation is the stage that can make or break an assay’s performance. Preserving the natural state of samples without having to sacrifice population size can be the difference between innovation and stagnation. Now more than ever, we need dependable, reproducible results that don’t require a lab magician. With Laminar Wash, we can […]
How to wash away barriers to therapeutic cancer vaccine development
Developing neoantigen-based cancer vaccines necessitates comprehensive cellular characterization for iterative therapeutic improvement, which Laminar Wash™ systems may facilitate at multiple steps. Vaccines are probably the second-most effective advancement in the annals of human medicine, after sanitation. Most of us recognize the value of vaccines in infectious disease. Yet, swept under the rug amongst the COVID-19 global pandemic is another form of immune-boosting injection combating a terrible […]
Centrifuge-less Immuno-staining of Cells for Superior Viability, Recovery & Data
Now Watchinghttps://www.youtube.com/watch?v=kAUfEX1oQKY This webinar is presented by Sue Reynolds, Ph.D. Sue has extensive flow cytometry experience working in industry as a flow core manager, application scientist, field marketing and market development manager. Watch this webinar to learn about: Impacts of centrifugation on your cell samples and data Introduction to the working principles and products of […]
Centrifuge-less Immuno-staining of Cells for Superior Viability, Recovery & Data
Now Watching To see the full webinar, fill out the form below: https://www.youtube.com/watch?v=r9xM9rcCJCg
Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells
READ JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Kang H-J, Kim G-C, Lee C-G, et al. Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3+ regulatory T cells. Journal of Allergy and Clinical Immunology. 2020. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the […]