Myeloid cells are a diverse group of immune cells derived from hematopoietic stem cells in bone marrow. They play a crucial role in both innate and adaptive immunity. Among the most important myeloid cells are dendritic cells and macrophages.
Dendritic cells’ primary function is to process and present antigens to T cells, initiating and shaping the adaptive immune response. They are found in tissues that are in contact with the external environment (i.e., skin), blood and lymphoid organs.
Macrophages are highly efficient at engulfing and digesting cellular debris, pathogens, and apoptotic cells. They are present in virtually all tissues, where they adapt to tissue-specific functions.
Both types of cells play critical roles in responding to infections by pathogens. Dendritic cells are used in cancer vaccines to stimulate the immune response against tumors, while macrophages are used for enhancing immune responses against tumors or modulating them to reduce inflammation in chronic diseases.
