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Laminar Wash technology supported this study from the University of Surrey and King’s College London that used single-cell transcriptomics immune cell reference datasets to better classify rare B cell subsets within the larger peripheral blood mononuclear cell (PBMC) landscape.
Sahir F, Mateo JM, Steinhoff M, Siveen KS. Development of a 43 color panel for the characterization of conventional and unconventional T-cell subsets, B cells, NK cells, monocytes, dendritic cells, and innate lymphoid cells using spectral flow cytometry. Cytometry Part A. 2020;n/a(n/a).
Researchers at the University of Chicago used their Laminar Wash HT2000 system to safely prepare peripheral immune cells from COVID-19 patients with moderate and severe disease for flow cytometry in a biosafety cabinet. This preprint manuscript in a Nature family journal reveals how increased IL-6 and CCL2 in patients with severe disease is likely derived…
Scientists at Eli Lilly were characterizing circulatory inflammatory profiles and underlying systemic disease heterogeneity within atopic dermatitis (AD) patients. The multiplexing study of several pro-inflammatory mediators distinguished between baseline disease severities, demonstrated by greater EASI, SCORAD Index, Itch NRS and DLQI scores. DropArray Technology provided a 5uL- sample volume workflow, which complies towards extended cytokine…
Investigators in Singapore utilized Curiox’s DropArray (LT210) multiplex immunoassay system to profile 45 cytokines, chemokines, and growth factors in children with severe and non-severe PARDS. This revealed a differential immunological signature correlating with early and late disease, shedding light on PARDs pathophysiology.
Arnold JW, Roach J, Fabela S, et al. The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut. Microbiome. 2021;9(1):31.
Zappasodi R, Serganova I, Cohen IJ, et al. CTLA-4 blockade drives loss of T reg stability in glycolysis-low tumours. Nature. 2021.
Zhou J, Chern BS, Barton-Smith P, et al. Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes. International Journal of Molecular Sciences. 2020;21(10).
Wu L, Seung E, Xu L, et al. Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation. Nature Cancer. 2020;1(1):86-98.