CAR T

Improve CAR T cell data while increasing the purity and viability of your cells

How Curiox Can Help

Preserve delicate sample types
Attain consistent and accurate results
See operational improvements

CAR T cells, or Chimeric Antigen Receptor T cells, are genetically engineered T cells used in immunotherapy to target and kill cancer cells. This approach combines the specificity of monoclonal antibodies with the cytotoxic potential of T cells.

T cells are collected from a patient’s blood through leukapheresis. These collected cells are genetically engineered to express CARs that target specific cancer antigens. They are then multiplied in the lab to increase their numbers. The engineered CAR T cells are infused back into the patient where they seek out and bind to cancer cells, expressing the target antigen, which leads to cancer cell destruction.

CAR T cells have shown significant success in treating blood cancers and research is ongoing in solid tumors. A key benefit is their personalized treatment, resulting in high efficacy. They can, however, cause severe side effects including cytokine release syndrome (CRS) and neurotoxicity. The process of generating CAR T cells is complex, time-consuming and expensive.

Areas involving CAR T cells include:

Cell and Gene Therapy. The accuracy of data and preservation of CAR T samples play a key role in success. Centrifuging samples during the many wash steps involved in a flow cytometry assay can hinder this success.
Rare cell populations. They make up about 1% of the population when working with CAR T cells. As such, retaining as many as possible is highly important.

How Curiox Can Help

Curiox products can help to preserve delicate sample types, retain rare cell populations, and show consistent and accurate results repeatedly, independent of operator skill or lab location. Customers have not only seen data quality consistency improvements, but operational improvements as well. With Curiox technologies, there is no more flicking, no more pellets being lost, and no more time spent waiting around a centrifuge.

Standardize your methods and enhance CAR T-cell data with products that provide automation, standardization, and reproducibility.

Watch these webinars to learn more:

Curiox specializes in automated sample preparation solutions that aid in accurate and reproducible cell analysis. Our collaboration aims to leverage their next-generation sample preparation platform and look deep into cellular analysis for hematological malignancies.