Validated 384-Well C-FREE™ Washing for High-Throughput Cell Prep
Validated 384-Well Centrifuge-Free Washing for High-Throughput Cell Prep Technical and biological validation of centrifuge-free washing at 384-well scale using the C-FREE™ Pluto platform. Enabling high-throughput cell prep automation Moving to 384-well formats increases throughput and reduces reagent use—but washing at this scale introduces real risks: sample loss, uneven retention, and assay variability. This application note […]
From Gentle Wash to Harmonized Workflows: How the Field Scaled Next
By Melvin Lye, Curiox Biosystems For much of the history of flow cytometry, centrifugation has been treated as an accepted compromise. It is efficient, familiar, and deeply embedded in laboratory practice. At the same time, its limitations (cell loss, mechanical stress, and operator-dependent variability) have long been recognized, even if rarely interrogated explicitly in published work. As […]
Harmonization in Cell Preparation: Preserving Data Comparability Across Sites, CROs, and Automation Platforms
By Mallory Griffin, Curiox Biosystems The problem: comparable data starts upstream Cell-based assays have benefited from major advances in instrumentation, reagents, and analysis software. Measurement technologies and data analysis are increasingly automated, standardized, and shared across organizations. Cell preparation, however, remains one of the least controlled parts of the workflow. Even when the same protocol […]
Shared Principles, Consistent Results: Pluto Wash vs. Laminar Wash
By Melvin Lye, Senior Director of Scientific Affairs Introduction: Questioning a Long-Held Belief For decades, suspension cell workflows followed a rigid belief: centrifugation and pelleting were the only way to wash cells. This dogma shaped countless assays but also introduced variability, operator fatigue, and cell loss. Curiox challenged this in 2018 with Laminar Wash™ (LW), proving that […]
Advancing Antibody Cocktail Solutions: Empowering CROs with Pluto Automation
By Melvin Lye, Senior Director of Scientific Affairs The preclinical CRO market is projected to reach USD 8.4 billion by 2030, driven by the rise in high-throughput studies and the demand for reproducible biomarker data in drug development. Yet, many Contract Research Organizations (CROs) still rely on manual pipetting for antibody cocktailing, creating bottlenecks that threaten […]
Standardizing Flow Cytometry
Thank you for Registering – Watch the Full Tutorial Below “Standardizing Flow Cytometry: Advances in Antibody Preparation and Automation for Reliable Immune Monitoring” – as presented at CYTO 2025 https://youtu.be/LRzSU3tURCA Understand the drivers of the reproducibility crisis in flow cytometry and its impact and the on clinical and research workflows. Key Takeaways: See practical solutions for […]
On-Demand: Standardizing Flow Cytometry
Unlock the full CYTO 2025 Commercial Tutorial featuring experts from Stanford University, NIST, Eurofins and Curiox Standardizing Flow Cytometry: Advances in Antibody Preparation and Automation for Reliable Immune Monitoring Understand the drivers of the reproducibility crisis in flow cytometry and its impact and the on clinical and research workflows. Key Takeaways: See practical solutions for automating sample […]
Beyond Centrifuges: How Smart Automation Transforms Lab Efficiency
By Vincent Andreala, Field Application Scientist | Edited by Melvin Lye, Senior Director of Scientific Affairs June 17, 2025 Introduction: Why Automation, Why Now? If you’ve ever found yourself wrestling with inconsistent data, backlogged experiments, or a constant hunt for trained personnel to manage delicate workflows—you’re not alone. The traditional approach to cell sample preparation has […]
POSTER 2025 CYTO – Clinical Laboratory Automation
Flow cytometry is a cornerstone of immunological diagnostics, providing precise insights into immune system health. However, modern clinical workflows face challenges related to efficiency, reproducibility, and operator fatigue due to high throughput demands. This poster presents the Curiox C-FREE Pluto system as a revolutionary solution addressing these challenges through automation and advanced features. Fill in […]
POSTER 2025 – Evaluating the Curiox C-FREE Pluto System for Whole Blood Immunophenotyping Sample Processing
Flow cytometry remains a critical tool for immunological research and diagnostics, yet traditional manual workflows can be labor-intensive and inconsistent. The Curiox C-FREE Pluto System (Pluto) introduces a fully-automated workflow solution, including antibody cocktailing, seamlessly integrating with conventional protocols without requiring adaptation. Pluto incorporates gentle washing of samples as opposed to harsh centrifugal forces with […]