POSTER—2025 SLAS – Evaluating the Curiox C-FREE Pluto System for Whole Blood Immunophenotyping Sample Processing
Flow cytometry remains a critical tool for immunological research and diagnostics, yet traditional manual workflows can be labor-intensive and inconsistent. The Curiox C-FREE Pluto System (Pluto) introduces a fully-automated workflow solution, including antibody cocktailing, seamlessly integrating with conventional protocols without requiring adaptation. Pluto incorporates gentle washing of samples as opposed to harsh centrifugal forces with […]
POSTER—2025 SLAS – Clinical Laboratory Automation
Flow cytometry is a cornerstone of immunological diagnostics, providing precise insights into immune system health. However, modern clinical workflows face challenges related to efficiency, reproducibility, and operator fatigue due to high throughput demands. This poster presents the Curiox C-FREE Pluto system as a revolutionary solution addressing these challenges through automation and advanced features. Download
Flow Cytometry Sample Preparation with an Automated, Centrifuge-Less Workflow Highlight
Now Watchinghttps://youtu.be/i2L6AP2rNWk In this video, Dr. Holden Maecker from Stanford University presents a centrifuge-less automation method for flow cytometry sample preparation. Traditionally, flow cytometry sample prep is a manual, labor-intensive process, often relying on large, costly liquid handling systems. However, Curiox C-FREE Pluto System, an automated system using laminar flow principles, offers an alternative by […]
Flow Cytometry Sample Preparation with an Automated, Centrifuge-Less Workflow
Now Watchinghttps://youtu.be/TRlVv0ALd_c In this video, Dr. Holden Maecker from Stanford University presents a centrifuge-less automation method for flow cytometry sample preparation. Traditionally, flow cytometry sample prep is a manual, labor-intensive process, often relying on large, costly liquid handling systems. However, Curiox C-FREE Pluto System, an automated system using laminar flow principles, offers an alternative by […]
Defining the bone marrow atlas with high-dimensional biology via a novel CITE-seq workflow
Now Watchinghttps://youtu.be/hD4OV9vf-Ak Single-cell multimodal approaches and machine learning are transforming analysis of the human hematopoietic progenitor compartment. Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) enables coupled surface protein and transcriptome profiling, revealing genomic programs underlying progenitor states. This webinar will present groundbreaking work establishing a high-resolution human bone marrow single-cell atlas using paired […]
Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies
Sixun Chen, Tan Dai Nguyen, Kang-Zheng Lee, Dan Liu, https://doi.org/10.1016/j.biotechadv.2024.108434 Adoptive immunotherapy shows great promise as a treatment for cancer and other diseases. Recent evidence suggests that the therapeutic efficacy of these cell-based therapies can be enhanced by the enrichment of less-differentiated T cell subpopulations in the therapeutic product, giving rise to a need for […]
POSTER—Replacing the centrifuge to increase T-cell recovery and generate consistent data: The Laminar Wash™ approach
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POSTER—2024 – An Automated, Centrifuge-Less Workflow for Cell Staining and Washing of Flow and Mass Cytometry Samples
Flow cytometry is widely used in research and clinical settings, but automating sample preparation remains a challenge due to the high cost and large footprint of traditional liquid handling systems. Curiox’s Centrifuge-Less (C-FREE™) technology offers a smaller, more cost-effective solution by using laminar flow to wash and stain cells in 96-well plates without centrifugation. C-FREE™ […]
Breathe Easy with Better Models
Now Watching Research for Activating Macrophages and Dendritic Cells with Nanomedicine in Lung Carcinoma https://youtu.be/wljKOIcYsUM Macrophages can mediate phagocytosis of cancer cells and cytotoxic tumor killing, and engage in effective bidirectional interactions with components of the innate and adaptive immune system. Given the continuous recruitment of myelomonocytic cells into tumor tissues, macrophages are candidates for […]
An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors
Zhang, X., Song, B., Carlino, M. J., Li, G., Ferchen, K., Chen, M., Thompson, E. N., Kain, B. N., Schnell, D., Thakkar, K., Kouril, M., Jin, K., Hay, S. B., Sen, S., Bernardicius, D., Ma, S., Bennett, S. N., Croteau, J., Salvatori, O., . . . Grimes, H. L. (2024). Nature Immunology, 25(4), 703–715. https://doi.org/10.1038/s41590-024-01782-4 […]