Category: Flow Cytometry

High-throughput workflow leveraging spectral flow cytometry and CITE-seq to characterize human bone marrow across race and gender

Song, B., Zhang, X., Bennett, S., Ma, S., Ferchen, K., Salomonis, N., & Grimes, H. L. (2023). The Journal of Immunology, 210(1_Supplement), 250.13. https://doi.org/10.4049/jimmunol.210.supp.250.13 Characterizing human bone marrow is challenging due to heterogeneity of cell types, and the rarity of some populations. To address this, we developed a workflow that bridges CITE seq and flow […]

Critical Quality Metrics in Cell Sample Prep for Cell & Gene Therapy Bioanalytics

Now Watchinghttps://youtu.be/vEgp_FSQHF8 In this panel discussion, Virginia Litwin, Ph.D. (CRL), Christoph Eberle, MICR, FRSPH (CRL), Mahwish Natalia, MA, Ph.D. (Takeda Oncology), and Melvin Lye, MBA (Curiox Biosystems) discuss the role of partnerships between early- and late-stream analytical assay developers. While tackling unique challenges in validating flow cytometric methods for Chimeric Antigen Receptor (CAR) T cells, […]

Could Debris Be Masking Your True Results

Now Watchinghttps://www.youtube.com/watch?v=TlQaihGArto Sample preparation is the stage that can make or break an assay’s performance. Preserving the natural state of samples without having to sacrifice population size can be the difference between innovation and stagnation. Now more than ever, we need dependable, reproducible results that don’t require a lab magician. With Laminar Wash, we can […]

Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction

READ NATURE PORTFOLIO PREPRINT Researchers at the University of Chicago used their Laminar Wash HT2000 system to safely prepare peripheral immune cells from COVID-19 patients with moderate and severe disease for flow cytometry in a biosafety cabinet. This preprint manuscript in a Nature family journal reveals how increased IL-6 and CCL2 in patients with severe […]

AUTO1000: Automate Your Cell Staining Workflow

The Curiox Laminar Wash AUTO 1000 System completely automates the staining and washing workflow, eliminating a major source of variability and enabling process standardization. The AUTO 1000 system offers several key benefits to research and shared resource laboratories in cell and gene therapy discovery and process development, antibody screening, flow core labs, and other applications that rely on cell-based assays.

Enabling Single-cell Multiomics and Cell Hashing in Studies with Limited Numbers of Cells

Now Watchinghttps://youtu.be/LagyuoWvELo Our October 19, 2021 webinar featured University of Gothenburg Associate Professor of Immunology Mats Bemark, Ph.D. and Curiox Biosystems Marketing & Content Manager, Geoffrey Feld, Ph.D. Dr. Bemark studies mucosal immunology, with particular focus on the gut and gut-related infections like cholera, and recently has been working on COVID-19 with human severe disease samples. His […]

Manufacturing Living Therapies

Enabling “next-generation” drugs through automation and standardization This article was first published on Charles River Laboratories Eureka Blog. Please support our partners at Charles River. Cell and gene therapy continues to drive biopharmaceutical investment and pipelines, despite COVID-related research and clinical trial disruptions. Last year, the global cell therapy market size was $7.8 billion, expanding annually […]