Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
Lim JS, Ibaseta A, Fischer MM, et al. Nature. 2017;545(7654):360-364. READ NATURE Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling
READ PUBMED Cancerous tumors grow and prosper in an inflammatory environment at the intersection of many signaling pathways in the immune system. Since tumors exist in such a complex environment, researchers have been interested in how targeting components and molecules in these signaling pathways could enable targeted therapy for cancer patients. The main challenge in […]
Surfaceome mapping of primary human heart cells with CellSurfer uncovers cardiomyocyte surface protein LSMEM2 and proteome dynamics in failing hearts
Luecke, L. B., Waas, M., Littrell, J., Wojtkiewicz, M., Castro, C., Burkovetskaya, M., Schuette, E. N., Buchberger, A. R., Churko, J. M., Chalise, U., Waknitz, M., Konfrst, S., Teuben, R., Morrissette-McAlmon, J., Mahr, C., Anderson, D. R., Boheler, K. R., & Gundry, R. L. (2023). Nature Cardiovascular Research, 2(1), 76–95. https://doi.org/10.1038/s44161-022-00200-y Cardiac cell surface proteins […]
White Paper—Improved Sample Preparation for Immuno-oncology Studies
Download the White Paper: Improved sample preparation for immuno-oncology studies
How to wash away barriers to therapeutic cancer vaccine development
Developing neoantigen-based cancer vaccines necessitates comprehensive cellular characterization for iterative therapeutic improvement, which Laminar Wash™ systems may facilitate at multiple steps. Vaccines are probably the second-most effective advancement in the annals of human medicine, after sanitation. Most of us recognize the value of vaccines in infectious disease. Yet, swept under the rug amongst the COVID-19 global pandemic is another form of immune-boosting injection combating a terrible […]
Functional profiling of nucleotide Excision repair in breast cancer
READ JOVE Rajkumar-Calkins AS, Szalat R, Dreze M, et al. DNA Repair. 2019;82:102697. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
Nucleotide excision repair is a potential therapeutic target in multiple myeloma
READ JOVE Szalat R, Samur MK, Fulciniti M, et al. Nucleotide excision repair is a potential therapeutic target in multiple myeloma. Leukemia. 2017;32:111. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
READ NATURE CANCER Wu L, Seung E, Xu L, et al. Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation. Nature Cancer. 2020;1(1):86-98. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications
READ JOVE Donnenberg AD, Luketich JD, Donnenberg VS. Oncotarget. 2019;10(60):6456-6465. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors
READ JOVE Francica BJ, Ghasemzadeh A, Desbien AL, et al. Cancer Immunology Research. 2018;6(4):422. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.