Immunopeptidomic MHC-I Profiling and Immunogenicity Testing Identifies Tcj2 as a New Chagas Disease mRNA Vaccine Candidate
Versteeg, L., Adhikari, R., Robinson, G., Lee, J., Wei, J., Islam, N., Keegan, B., Russell, W. K., Poveda, C., Villar, M. J., Jones, K., Bottazzi, M. E., Hotez, P., Tijhaar, E., & Pollet, J. (2024). PLoS Pathogens, 20(12), e1012764. https://doi.org/10.1371/journal.ppat.1012764 Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million […]
Higher debris removal–CRX-CRL_TIL-whitepaper_apr2021.pdf
https://staging.curiox.com/wp-content/uploads/2024/08/CRX-CRL_TIL-whitepaper_apr2021.pdf
Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Guo, Y., Bao, Q., Hu, P., & Shi, J. (2023). Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42972-2 Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy. Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral macrophages and dendritic cells. Using a layered double hydroxide nanosheet carrier, we co-deliver a T-type calcium channel inhibitor (TTA-Q6) and […]
Critical Quality Metrics in Cell Sample Prep for Cell & Gene Therapy Bioanalytics
Now Watchinghttps://youtu.be/vEgp_FSQHF8 In this panel discussion, Virginia Litwin, Ph.D. (CRL), Christoph Eberle, MICR, FRSPH (CRL), Mahwish Natalia, MA, Ph.D. (Takeda Oncology), and Melvin Lye, MBA (Curiox Biosystems) discuss the role of partnerships between early- and late-stream analytical assay developers. While tackling unique challenges in validating flow cytometric methods for Chimeric Antigen Receptor (CAR) T cells, […]
Could Debris Be Masking Your True Results
Now Watchinghttps://www.youtube.com/watch?v=TlQaihGArto Sample preparation is the stage that can make or break an assay’s performance. Preserving the natural state of samples without having to sacrifice population size can be the difference between innovation and stagnation. Now more than ever, we need dependable, reproducible results that don’t require a lab magician. With Laminar Wash, we can […]
Laminar Wash™ Technology Enabled Accurate Identification of Tumor Infiltrating Lymphocyte (TIL) Population
Immunotherapy, a treatment that harnesses the patients’ own immune systems to fight off cancer, is revolutionizing cancer treatment. Since the original success in melanoma, significant advances have led to novel immunotherapeutic approaches for treatment of various types of cancer, with a large number of clinical trials being currently underway. The successful anti-tumor immune response is […]
Centrifuge-less Immuno-staining of Cells for Superior Viability, Recovery & Data
Now Watchinghttps://www.youtube.com/watch?v=kAUfEX1oQKY This webinar is presented by Sue Reynolds, Ph.D. Sue has extensive flow cytometry experience working in industry as a flow core manager, application scientist, field marketing and market development manager. Watch this webinar to learn about: Impacts of centrifugation on your cell samples and data Introduction to the working principles and products of […]
Centrifuge-less Immuno-staining of Cells for Superior Viability, Recovery & Data
Now Watching To see the full webinar, fill out the form below: https://www.youtube.com/watch?v=r9xM9rcCJCg
Poster—Curiox Laminar Wash AUTO system: a reliable walk-away sample preparation solution for better TILs recovery without centrifugation
This poster describes our AUTO1000 instrument, a fully turnkey, automated, walkaway cell preparation solution for flow cytometry without centrifugation. It features an intuitive user interface for generating custom assays and little training. The utility is demonstrated with superior recovery of tumor infiltrating leukocytes (TILs) from dissociated tumors. Please click here to watch a short video of the […]
Development of a 43 color panel for the characterization of conventional and unconventional T‐cell subsets, B cells, NK cells, monocytes, dendritic cells, and innate …
Sahir, F., Mateo, J. M., Steinhoff, M., & Siveen, K. S. (2020). Cytometry Part A, 105(5), 404–410. https://doi.org/10.1002/cyto.a.24288 Although many flow cytometers can analyze 30–50 parameters, it is still challenging to develop a 40+ color panel for the phenotyping of immune cells using fluorochrome conjugated antibodies due to limitations in the availability of spectrally unique […]