Automated Characterization Method for Validation of Epigenomic Editors in T Cells
Now Watchinghttps://youtu.be/-oRv-U2VMHg To view the transcript click here. Robust characterization methods are important analytical tools for phenotypic characterization in cell and gene therapy. For high-parameter flow cytometry methods, sample preparation is a highly complex and mostly manual procedure. Traditional flow cytometry methods are limited in throughput and resource intensive, which make them suboptimal for discovery screening […]
Critical Quality Metrics in Cell Sample Prep for Cell & Gene Therapy Bioanalytics
Now Watchinghttps://youtu.be/vEgp_FSQHF8 In this panel discussion, Virginia Litwin, Ph.D. (CRL), Christoph Eberle, MICR, FRSPH (CRL), Mahwish Natalia, MA, Ph.D. (Takeda Oncology), and Melvin Lye, MBA (Curiox Biosystems) discuss the role of partnerships between early- and late-stream analytical assay developers. While tackling unique challenges in validating flow cytometric methods for Chimeric Antigen Receptor (CAR) T cells, […]
Automating Cell Therapy Product: Constraints and Product Qualification for Fit-to-Process
Now Watchinghttps://www.youtube.com/watch?v=s-ptVJc2HpU When cells matter, it is key to prioritize their care at every stage. Clear resolution and retention of rare cell populations proves to be an issue in cell therapy processing utilizing traditional centrifugation methods. Automated, reproducible sample prep that does not rely on manual handling is the missing piece to saving precious samples, […]
Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Now Watching Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries Elijah W. Chen*1, Chyan Ying Ke*2,3, Joanna Brzostek*1, Nicholas R. J. Gascoigne1, Vasily Rybakin1,41Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 2Singapore Immunology Network, A*STAR, 3Curiox Biosystems, 4Department of Immunobiology, Rega Institute for Medical Research, Katholieke Universiteit (KU) Leuven * These authors […]
Development of Centrifuge Independent Assays for Investigating T cell Signaling Pathways
Now Watchinghttps://www.youtube.com/watch?v=PtgqPNdoEeE Dr. Joanna Brzostek and Elijah Chen, of Dr. Nicholas Gascoigne’s Laboratory at National University of Singapore, describe their use of Laminar Wash technology (FKA DA-Cell) and T-cell activation, both looking at thymocytes and peripheral T-cells. In their work they encounter some very common problems, some of which are related to looking at the […]
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
READ JOVE cGovern N, Shin A, Low G, et al. Nature. 2017;advance online publication. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant mesothelioma: therapeutic implications
READ JOVE Donnenberg AD, Luketich JD, Donnenberg VS. Oncotarget. 2019;10(60):6456-6465. Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.