Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
Athos Silva De Oliveira, Leroy Versteeg, Neima Briggs, Rakesh Adhikari, Maria Jose Villar, JeAnna R. Redd, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet; https://doi.org/10.1371/journal.pntd.0012809 Publication Summary In this study, researchers investigated how altering the intracellular trafficking of the Necator americanus glutathione-S-transferase-1 (Na-GST-1) antigen affects immunogenicity and vaccine candidate performance. By engineering secreted and membrane-anchored forms […]