Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells
Wang et al., 2024, Cancer Cell 42, 1–16 In the new era of cancer treatment, immunotherapy has become a revolutionary therapeutic approach. Particularly, immune checkpoint inhibitors such as anti-PD-1 and anti-CTLA-4 antibodies have significantly improved the survival rates of patients with various types of cancer. Immune checkpoint inhibitors enhance the body’s immune response to cancer […]
Profiling Circulating T cells and Tumor Landscape for Predicting Responses to PD-1 blockade in Patients with Non-Small Cell Lung Cancer
Dutta, N. (2024, September 5). https://gupea.ub.gu.se/handle/2077/81804 Immune checkpoint blockade (ICB) has significantly improved outcomes in non-small cell lung cancer (NSCLC), yet only a subset of patients achieves durable responses. This underscores the need for effective methods to assess ICB efficacy. This thesis investigates the response to PD-1 blockade in NSCLC patients across stages I to […]
POSTER 2024 – An Automated, Centrifuge-Less Workflow for Cell Staining and Washing of Flow and Mass Cytometry Samples
Flow cytometry is widely used in research and clinical settings, but automating sample preparation remains a challenge due to the high cost and large footprint of traditional liquid handling systems. Curiox’s Centrifuge-Less (C-FREE™) technology offers a smaller, more cost-effective solution by using laminar flow to wash and stain cells in 96-well plates without centrifugation. C-FREE™ […]
Resistance of CAR-T Immunotherapy For Hematological Cancers
Now Watchinghttps://youtu.be/-09n_Qib-co Explore the advancements in CAR-T immunotherapy for relapsed/refractory B cell lymphomas and leukemia in an exclusive webcast featuring Dr. Marco Ruella, a distinguished expert in cellular immunotherapies. Dr. Ruella’s presentation will showcase innovative research focusing on enhancing CAR-T therapy by uncovering tumor evasion mechanisms and addressing challenges in CAR-T cell dysfunction and the […]
Resistance of CAR-T Immunotherapy For Hematological Cancers
Now Watchinghttps://youtu.be/-09n_Qib-co Explore the advancements in CAR-T immunotherapy for relapsed/refractory B cell lymphomas and leukemia in an exclusive webcast featuring Dr. Marco Ruella, a distinguished expert in cellular immunotherapies. Dr. Ruella’s presentation will showcase innovative research focusing on enhancing CAR-T therapy by uncovering tumor evasion mechanisms and addressing challenges in CAR-T cell dysfunction and the […]
Nasal tissue-resident memory CD4+ T cells persist after influenza A virus infection and provide heterosubtypic protection
NimithaR. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Anneli Strömberg, Nils Lycke, Mats Bemark, Ka-Wei Tang, Davide Angelettihttps://doi.org/10.1101/2024.07.06.602325 CD4 tissue-resident memory T (CD4 TRM) cells are crucial adaptive immune components involved in preventing influenza A virus (IAV) infection. Despite their importance, their physiological role in the upper respiratory tract, the first site of contact with IAV, remains unclear. Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the […]
A unified model-based framework for doublet or multiplet detection in single-cell multiomics data
Hu, H., Wang, X., Feng, S., Xu, Z., Liu, J., Heidrich-O’Hare, E., Chen, Y., Yue, M., Zeng, L., Rong, Z., Chen, T., Billiar, T., Ding, Y., Huang, H., Duerr, R. H., & Chen, W. (2024). Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-49448-x Droplet-based single-cell sequencing techniques rely on the fundamentalassumption that each droplet encapsulates a single cell, enabling […]
Curiox Biosystems Establishes Innovation Center at Stanford University
Curiox Biosystems Announces the Establishment of the Curiox Innovation Center for the Curiox C-FREE™ Pluto LT System at Stanford University’s Human Immune Monitoring Center SAN FRANCISCO, June 25, 2024 /PRNewswire/ — Curiox Biosystems, a global leader in providing innovative and automated sample preparation solutions for accurate and reproducible cell analysis, is pleased to announce the establishment of the […]
Protocol to characterize immune cell subpopulations in cerebrospinal fluid of patients with neuroinflammatory diseases using mass cytometry
Gallaccio, G., Wang, M., Schlickeiser, S., Kunkel, D., Böttcher, C., & Fernández-Zapata, C. (2024). STAR Protocols, 5(2), 103038. https://doi.org/10.1016/j.xpro.2024.103038 Phenotypic and compositional changes of immune cells in cerebrospinal fluid (CSF) can be used as biomarkers to help diagnose and track disease activity for neuroinflammatory and neurodegenerative diseases. Here, we present a workflow to perform high-dimensional […]
Join Us at 47th Annual Course in Cytometry!
Curiox Biosystems will be sponsoring the 47th Annual Course in Cytometry. This prestigious event will be held from June 8 – 13 at the University of Wisconsin, Madison, WI. We invite you to attend our presentation and learn more about how our technology at these two opportunities. (1) Presentation: Date & Time: Sunday, June 9, 3:00PM […]