Surfaceome mapping of primary human heart cells with CellSurfer uncovers cardiomyocyte surface protein LSMEM2 and proteome dynamics in failing hearts
READ NATURE Cell surface proteins (surfaceome) play a significant role in the development of novel target therapies. Therefore, a comprehensive surfaceome profiling approach is necessary to identify and quantify specific markers for effective therapeutic targeting. The challenge most developers face is the lack of data due to complex methodologies, rare cell types and/or small number […]
Brochure—AUTO 1000 System
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Longitudinal single-cell analysis of SARS-CoV-2–reactive B cells uncovers persistence of early-formed, antigen-specific clones
Scharf, L., Axelsson, H., Emmanouilidi, A., Mathew, N. R., Sheward, D. J., Leach, S., Isakson, P., Smirnov, I. V., Marklund, E., Miron, N., Andersson, L., Gisslén, M., Murrell, B., Lundgren, A., Bemark, M., & Angeletti, D. (2022). JCI Insight, 8(1). https://doi.org/10.1172/jci.insight.165299 Understanding persistence and evolution of B cell clones after COVID-19 infection and vaccination is […]
Using high throughput technologies to understand heterogeneous drug response
GE Boyle (2023), University of Washington Heterogeneity is an inherent quality of biological systems, and is one of the properties that facilitates adaptation of organisms to new environments and stimuli. However, the scientific method relies on probabilistic reasoning wherein sample measurements are assumed to represent the population as a whole. In situations where this assumption […]
Overcoming challenges of Nuclei and Cell Preparation: A scientific perspective by S2 genomics and Curiox Story
Now Watchinghttps://youtu.be/inLymDAn4EI Single-cell transcriptome analysis has been extensively applied in humans and animal models to uncover gene expression heterogeneity between the different cell types of a tissue or an organ. Upstream processing may introduce inherent challenges that mask true analysis and increase user variability. Here we present a simple, yet combinatorial strategy from buffer and […]
Impact of Novel Curiox Laminar Wash on Nuclei Retention and Other Downstream Applications
Now Watchinghttps://youtu.be/U0oWMffKFlM Cell type-specific nuclei populations can be used for a wide range of downstream sequencing applications including transcriptomic and epigenomic analyses. Cerevance’s breakthrough use of Laminar Wash™ Technology in their proprietary NETSseq platform has enabled an improvement in nuclei retention as well as reagent cost reductions and time savings. This Labroots Webinar features David […]
Could Debris Be Masking Your True Results
Now Watchinghttps://www.youtube.com/watch?v=TlQaihGArto Sample preparation is the stage that can make or break an assay’s performance. Preserving the natural state of samples without having to sacrifice population size can be the difference between innovation and stagnation. Now more than ever, we need dependable, reproducible results that don’t require a lab magician. With Laminar Wash, we can […]
Automating Cell Therapy Product: Constraints and Product Qualification for Fit-to-Process
Now Watchinghttps://www.youtube.com/watch?v=s-ptVJc2HpU When cells matter, it is key to prioritize their care at every stage. Clear resolution and retention of rare cell populations proves to be an issue in cell therapy processing utilizing traditional centrifugation methods. Automated, reproducible sample prep that does not rely on manual handling is the missing piece to saving precious samples, […]
Automation Enables Innovation
“Time is currency. Be careful how you spend it.” – Byron L. Reeder Every second spent on manual processes is a second taken away from potential revenue. Every day, scientists are racing the clock between sample preparation, running experiments, analyzing data and much more. Juggling these responsibilities along with looming deadlines, while pushing for new […]
White Paper—The Cell Analysis Conundrum, Garbage In/Garbage Out
WHITEPAPER The Cell Analysis Conundrum—Garbage In / Garbage Out Why sample preparation determines the quality of your flow cytometry and single-cell data Centrifuge-less Higher Cell Recovery Reduced Debris Standardized Workflows The whitepaper shows why centrifuge-less Laminar Wash™ is the proven solution for high-quality cell sample preparation. C-FREE™ Pluto Wash builds on the same principle—gentle, controlled […]