Validated 384-Well C-FREE™ Washing for High-Throughput Cell Prep
Validated 384-Well Centrifuge-Free Washing for High-Throughput Cell Prep Technical and biological validation of centrifuge-free washing at 384-well scale using the C-FREE™ Pluto platform. Enabling high-throughput cell prep automation Moving to 384-well formats increases throughput and reduces reagent use—but washing at this scale introduces real risks: sample loss, uneven retention, and assay variability. This application note […]
From Gentle Wash to Harmonized Workflows: How the Field Scaled Next
By Melvin Lye, Curiox Biosystems For much of the history of flow cytometry, centrifugation has been treated as an accepted compromise. It is efficient, familiar, and deeply embedded in laboratory practice. At the same time, its limitations (cell loss, mechanical stress, and operator-dependent variability) have long been recognized, even if rarely interrogated explicitly in published work. As […]
Harmonization in Cell Preparation: Preserving Data Comparability Across Sites, CROs, and Automation Platforms
By Mallory Griffin, Curiox Biosystems The problem: comparable data starts upstream Cell-based assays have benefited from major advances in instrumentation, reagents, and analysis software. Measurement technologies and data analysis are increasingly automated, standardized, and shared across organizations. Cell preparation, however, remains one of the least controlled parts of the workflow. Even when the same protocol […]
The Automation Conversation: What Pharma and Flow Cores Can Learn from Each Other
WEBINAR The Automation Conversation: What Pharma and Flow Cores Can Learn from Each Other Experts from AbbVie and GLIIFCA on modernizing flow cytometry workflows with automation “We had a bunch of disparate instruments and I had to carry plates from one instrument to another…The missing link was washing.” -Ryan Duggan AbbVie Get the Recording 60 […]
Shared Principles, Consistent Results: Pluto Wash vs. Laminar Wash
By Melvin Lye, Senior Director of Scientific Affairs Introduction: Questioning a Long-Held Belief For decades, suspension cell workflows followed a rigid belief: centrifugation and pelleting were the only way to wash cells. This dogma shaped countless assays but also introduced variability, operator fatigue, and cell loss. Curiox challenged this in 2018 with Laminar Wash™ (LW), proving that […]
Advancing Antibody Cocktail Solutions: Empowering CROs with Pluto Automation
Advancing Antibody Cocktail Solutions: Empowering CROs with Pluto Automation By Melvin Lye, Senior Director of Scientific Affairs The preclinical CRO market is projected to reach USD 8.4 billion by 2030, driven by the rise in high-throughput studies and the demand for reproducible biomarker data in drug development. Yet, many Contract Research Organizations (CROs) still rely on […]
Automating Flow Cytometry Sample Prep: An ROI Calculation
Automating Flow Cytometry Sample Prep: An ROI Calculation Manual flow cytometry sample preparation is labor-intensive and costly, with multiple touchpoints for antibody cocktail prep, cell lysis, and staining. Each manual step adds labor cost, training time, and risk of error. Here we highlight the ROI of automated sample preparation, showing how Pluto Workstation reduces hands-on […]
Beyond Centrifuges: How Smart Automation Transforms Lab Efficiency
By Vincent Andreala, Field Application Scientist | Edited by Melvin Lye, Senior Director of Scientific Affairs June 17, 2025 Introduction: Why Automation, Why Now? If you’ve ever found yourself wrestling with inconsistent data, backlogged experiments, or a constant hunt for trained personnel to manage delicate workflows—you’re not alone. The traditional approach to cell sample preparation has […]
Automating Antibody Prep for Master Mix in Flow Cytometry: Eliminating Costly Errors and Standardizing Workflows
By Raffaele Lu, Automation Engineer Lead | Edited by Melvin Lye, Senior Director of Scientific Affairs May 20, 2025 In the world of pharmaceutical research and clinical development, flow cytometry is a cornerstone of immune profiling, biomarker validation, and cell-based screening. As the field evolves toward increasingly complex, multi-parameter panels, one critical aspect of the […]
Curiox Biosystems and Calebio Announce Strategic Partnership to Advance Automation in Flow Cytometry Across China
Exclusive Distribution Agreement Signed for Pluto Workstations to Expand Full-Spectrum Flow Cytometry Integration SEOUL, Korea/ Nanjing, China April 29, 2025 — Curiox Biosystems Co. Ltd, global leader in automated sample preparation for flow cytometry and single-cell analysis, today announced the signing of an exclusive distribution agreement with Calebio, a pioneering developer of full-spectrum flow cytometers […]