Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies
Sixun Chen, Tan Dai Nguyen, Kang-Zheng Lee, Dan Liu, https://doi.org/10.1016/j.biotechadv.2024.108434 Adoptive immunotherapy shows great promise as a treatment for cancer and other diseases. Recent evidence suggests that the therapeutic efficacy of these cell-based therapies can be enhanced by the enrichment of less-differentiated T cell subpopulations in the therapeutic product, giving rise to a need for […]
Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells
Wang et al., 2024, Cancer Cell 42, 1–16 In the new era of cancer treatment, immunotherapy has become a revolutionary therapeutic approach. Particularly, immune checkpoint inhibitors such as anti-PD-1 and anti-CTLA-4 antibodies have significantly improved the survival rates of patients with various types of cancer. Immune checkpoint inhibitors enhance the body’s immune response to cancer […]
Resistance of CAR-T Immunotherapy For Hematological Cancers
Now Watchinghttps://youtu.be/-09n_Qib-co Explore the advancements in CAR-T immunotherapy for relapsed/refractory B cell lymphomas and leukemia in an exclusive webcast featuring Dr. Marco Ruella, a distinguished expert in cellular immunotherapies. Dr. Ruella’s presentation will showcase innovative research focusing on enhancing CAR-T therapy by uncovering tumor evasion mechanisms and addressing challenges in CAR-T cell dysfunction and the […]
Resistance of CAR-T Immunotherapy For Hematological Cancers
Now Watchinghttps://youtu.be/-09n_Qib-co Explore the advancements in CAR-T immunotherapy for relapsed/refractory B cell lymphomas and leukemia in an exclusive webcast featuring Dr. Marco Ruella, a distinguished expert in cellular immunotherapies. Dr. Ruella’s presentation will showcase innovative research focusing on enhancing CAR-T therapy by uncovering tumor evasion mechanisms and addressing challenges in CAR-T cell dysfunction and the […]
Breathe Easy with Better Models
Now Watching Research for Activating Macrophages and Dendritic Cells with Nanomedicine in Lung Carcinoma https://youtu.be/wljKOIcYsUM Macrophages can mediate phagocytosis of cancer cells and cytotoxic tumor killing, and engage in effective bidirectional interactions with components of the innate and adaptive immune system. Given the continuous recruitment of myelomonocytic cells into tumor tissues, macrophages are candidates for […]
Single cell view of tumor microenvironment gradients in pleural mesothelioma
Giotti, B., Dolasia, K., Zhao, W., Cai, P., Sweeney, R., Merritt, E., Kiner, E., Kim, G. S., Bhagwat, A., Nguyen, T., Hegde, S., Fitzgerald, B. G., Shroff, S., Dawson, T., Garcia-Barros, M., Abdul-Ghafar, J., Chen, R., Gnjatic, S., Soto, A., . . . Tsankov, A. M. (2024). Cancer Discovery, 14(11), 2262–2278. https://doi.org/10.1158/2159-8290.cd-23-0017 Immunotherapies have shown […]
Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function
Jain, N., Zhao, Z., Koche, R. P., Antelope, C., Gozlan, Y., Montalbano, A., Brocks, D., Lopez, M., Dobrin, A., Shi, Y., Gunset, G., Giavridis, T., & Sadelain, M. (2023). Cancer Discovery, 14(1), 142–157. https://doi.org/10.1158/2159-8290.cd-22-1319 Suboptimal functional persistence limits the efficacy of adoptive T cell therapies. CD28-based chimeric antigen receptors (CARs) impart potent effector function to […]
Reinvigoration of Progenitor-Exhausted CD8 T Cells by anti-CTLA-4 Contributes to the Sustained Activity of Combination Checkpoint Blockade
Wang, Kevin and Coutifaris, Paulina and Brocks, David and Solis, Sabrina and Han, Nicholas and Manne, Sasikanth and Kiner, Evgeny and Sachar, Chirag and George, Sangeeth and Yan, Patrick and Kier, Melanie W. and Laughlin, Amy I. and Kothari, Shawn and Giles, Josephine R. and Mathew, Divij and Ghinnagow, Rheem and Alanio, Cecile and Flowers, […]