Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells
Guan, X., Hu, R., Choi, Y., Srivats, S., Nabet, B. Y., Silva, J., McGinnis, L., Hendricks, R., Nutsch, K., Banta, K. L., Duong, E., Dunkle, A., Chang, P. S., Han, C., Mittman, S., Molden, N., Daggumati, P., Connolly, W., Johnson, M., . . . Patil, N. S. (2024). Anti-TIGIT antibody improves PD-L1 blockade through myeloid […]
Immunomodulatory effects and improved outcomes with cisplatin-versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
Galsky, M. D., Guan, X., Rishipathak, D., Rapaport, A. S., Shehata, H. M., Banchereau, R., Yuen, K., Varfolomeev, E., Hu, R., Han, C., Li, H., Liang, Y., Vucic, D., Wang, L., Zhu, J., Yu, H., Herbst, R. H., Hajaj, E., Kiner, E., . . . Mariathasan, S. (2024). Cell Reports Medicine, 5(2), 101393. https://doi.org/10.1016/j.xcrm.2024.101393 In metastatic urothelial […]
A novel mass cytometry protocol optimized for immunophenotyping of low-frequency antigen- specific T cells
Balz, K., Grange, M., Pegel, U., Karamya, Z. A., Mello, M., Zhou, X., Berger, T., Bloch, K., Dunham, D., Chinthrajah, S., Nadeau, K., Luche, H., & Skevaki, C. (2024b). Frontiers in Cellular and Infection Microbiology, 13. https://doi.org/10.3389/fcimb.2023.1336489 Understanding antigen-specific T-cell responses, for example, following virus infections or allergen exposure, is of high relevance for the […]
Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T cell function
Jain, N., Zhao, Z., Koche, R. P., Antelope, C., Gozlan, Y., Montalbano, A., Brocks, D., Lopez, M., Dobrin, A., Shi, Y., Gunset, G., Giavridis, T., & Sadelain, M. (2023). Cancer Discovery, 14(1), 142–157. https://doi.org/10.1158/2159-8290.cd-22-1319 Suboptimal functional persistence limits the efficacy of adoptive T cell therapies. CD28-based chimeric antigen receptors (CARs) impart potent effector function to […]
The GENTIL Method for Isolation of Human Adult Cardiomyocytes from Cryopreserved Tissue for Proteomic Analyses
Waknitz, M., Luecke, L. B., Mesidor, R., Wojtkiewicz, M., Castro, C., & Gundry, R. L. (2023). Methods in Molecular Biology, 145–167. https://doi.org/10.1007/978-1-0716-3527-8_9 Heart failure is a serious clinical and economic health care problem, and its clinical progression is linked to pathological cardiac remodeling. Due to the heterogeneity of heart failure, lack of animal models to […]
Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Guo, Y., Bao, Q., Hu, P., & Shi, J. (2023). Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-42972-2 Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy. Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral macrophages and dendritic cells. Using a layered double hydroxide nanosheet carrier, we co-deliver a T-type calcium channel inhibitor (TTA-Q6) and […]
Reinvigoration of Progenitor-Exhausted CD8 T Cells by anti-CTLA-4 Contributes to the Sustained Activity of Combination Checkpoint Blockade
Wang, Kevin and Coutifaris, Paulina and Brocks, David and Solis, Sabrina and Han, Nicholas and Manne, Sasikanth and Kiner, Evgeny and Sachar, Chirag and George, Sangeeth and Yan, Patrick and Kier, Melanie W. and Laughlin, Amy I. and Kothari, Shawn and Giles, Josephine R. and Mathew, Divij and Ghinnagow, Rheem and Alanio, Cecile and Flowers, […]
High-throughput workflow leveraging spectral flow cytometry and CITE-seq to characterize human bone marrow across race and gender
Song, B., Zhang, X., Bennett, S., Ma, S., Ferchen, K., Salomonis, N., & Grimes, H. L. (2023). The Journal of Immunology, 210(1_Supplement), 250.13. https://doi.org/10.4049/jimmunol.210.supp.250.13 Characterizing human bone marrow is challenging due to heterogeneity of cell types, and the rarity of some populations. To address this, we developed a workflow that bridges CITE seq and flow […]
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer
Lim JS, Ibaseta A, Fischer MM, et al. Nature. 2017;545(7654):360-364. READ NATURE Subscribe to our newsletter Get updates about upcoming webinar technical application information and product announcements when you subscribe to the Curiox newsletter.
Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen-specific clones
READ PUBMED When the body encounters a pathogen, such as a virus, the immune system develops an adaptive immune response through B-cell and T-cell responses to clear the infection and develop memory to this pathogen. This memory, often referred to as “immunological memory,” allows the body to respond more rapidly and specifically if it faces […]