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Large scale cytokine profiling uncovers elevated IL12‑p70 and IL‑17A in severe pediatric acute respiratory distress syndrome

READ SCIENTIFIC REPORTS Investigators in Singapore utilized Curiox’s DropArray (LT210) multiplex immunoassay system to profile 45 cytokines, chemokines, and growth factors in children with severe and non-severe PARDS. This revealed a differential immunological signature correlating with early and late disease, shedding light on PARDs pathophysiology. Judith Ju Ming Wong, Herng Lee Tan, Jieliang Zhou, Jan […]

Laminar Wash HT2000 plus Buffer Exchanger Virtual Demonstration

Now Watchinghttps://www.youtube.com/watch?v=v4TGUjS_bDg This video demonstrates the daily operation and utility of the Laminar WashTM HT2000 system, outfitted with a buffer exchanger to facilitate automation. Comprised of a prepriatary 96-well “wall-less” plate and a robotic fluidics instrument, the HT2000 is the ideal solution to the reproducible and hands-free preparation of suspension cell samples for flow cytometry and single-cell ‘omics applications. Additionally, […]

Integration of Curiox Laminar Wash HT2000 with Thermo Scientific Orbitor and PAA S-Lab Plate Handlers

Now Watchinghttps://www.youtube.com/watch?v=WEsZ9VpO2eo In this video, the utility of the Laminar Wash HT2000 system for automating cell suspension sample prep workflows is demonstrated. The HT2000 instrument is compatible with a range of robotic plate mover systems to facilitate antibody screening, cell and gene therapy analytical and process development, and other high throughput applications where hands-off time, reproducibility, and […]

Laminar Wash AUTO1000 Daily Operation

Now Watchinghttps://www.youtube.com/watch?v=aTN8Pk40n1I This video demonstrates the daily operation and utility of the Laminar WashTM AUTO1000 system. Note that the video was recorded using a previous version of the AUTO1000 (the current model utilizes the upgraded HT2000 washing system that sports a touch screen). The system is comprised of the HT2000 washing station housed in an extended Hamilton NIMBUS pipetting workstation, […]

Towards standardizing flow cytometry sample preparation protocols without centrifugation

Now Watchinghttps://youtu.be/NTTfiQiqhqE In this sponsored webinar by the flowcytometryUK society webinar, renowned flow cytometrist Derek Davies, Ph.D. of the Francis Crick Institute hosted a discussion featuring Curiox Applications Scientist Noma Ngwenya and Charles River Laboratories Principal Scientist III and Flow Cytometry Core Director Christoph Eberle, Ph.D.  They explored how Laminar Wash™ technology enhances sample preparation for flow cytometry by […]

A Missing Sample Prep Tool for Single-Cell Biology is Found

Gentle and semi-automated Laminar Wash™ technology removes background, debris, doublets, and dead time, extending single-cell ‘omics budgets. Single-cell ‘omics technologies are achieving a new paradigm in biology. As Eadweard Muybridge applied photography to settle the “unsupported transit” controversy surrounding the 19th century galloping horse, immunologists are utilizing single-cell transcriptomics (scRNA) to tease apart the heterogeneity […]

Centrifuge vs Laminar Wash HT2000 Time-Motion Study

Now Watchinghttps://www.youtube.com/watch?v=MeR1PdvoR7g This time-motion study aims to assess and compare features of two different cell sample preparation methods, namely the conventional centrifugation method and the centrifuge-less Laminar Wash™ method. Traits such as the hands-on and walk-away times, as well as the complexity of movements required to interact with the instruments were evaluated. Materials and Methods Equivalent […]

Next-Generation Technology for Suspension Cell Preparation

Novel instrumentation enables gentle and consistent cell washing for researchers across the life sciences. This article was first published on Charles River Laboratories Eureka Blog. Please support our partners at Charles River. “The future is now” certainly rings true for biotechnology and medicine. Gene sequencing and editing have become routine, cell biology is understood enough […]

Curiox Laminar Wash Featured on Charles River Lab’s Eureka Science Blog

Collaboration with Charles River Laboratories expands Pharmaceutical and biotech companies, contract research organizations, and academics worldwide have discovered that Laminar Wash™ technology can improve their cellular analysis data quality and sample preparation workflows. Among Curiox’s customers is Charles River Laboratories (CRL), the world leader in addressing the challenges of pharmaceutical development. An early adopter of […]